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1,2-Acyl migration with α-imino rhodium carbenoids leading to substituted 1-naphthols.

Tomoya MiuraShunsuke MoritaniYota ShiratoriMasahiro Murakami
Published in: Chemical communications (Cambridge, England) (2022)
A unique method for the synthesis of substituted 1-naphthols by a rhodium(II)-catalysed ring-expansion reaction of 2-triazolyl-1-indanone derivatives is reported. 1,2-Acyl migration occurs with an intermediate α-imino rhodium carbenoid generated from the triazolyl moiety.
Keyphrases
  • molecular docking
  • fatty acid
  • molecular dynamics simulations