Seroprevalence of Coxiella burnetii in patients presenting with acute febrile illness at Marigat District Hospital, Baringo County, Kenya.
Allan P LemtudoBeth K MutaiLizzy MwamburiJohn N WaitumbiPublished in: Veterinary medicine and science (2021)
Q fever is not routinely diagnosed in Kenyan hospitals. This study reports on Q fever in patients presenting at Marigat District Hospital, Kenya, with febrile illness. ELISA was used to detect Coxiella burnetii phase antigens. Of 406 patients, 45 (11.1%) were judged to have acute disease (phase II IgM or IgG > phase I IgG), 2 (0.5%) were chronic (phase I IgG titer >800 or phase I IgG > phase II IgG), while 26 (6.4%) had previous exposure (phase I IgG titer <800). Age (6-10 years, p = 0.002) and contact with goats (p = 0.014) were significant risk factors. Compared to immunofluorescence antibody test, the sensitivity and specificity for phase I IgG were 84% and 98%, respectfully, 46% and 100% for phase II IgG and 35% and 89% for phase II IgM. It is concluded that the low sensitivity of phase II ELISA underestimated the true burden of acute Q fever in the study population.
Keyphrases
- phase ii
- clinical trial
- open label
- phase iii
- risk factors
- liver failure
- end stage renal disease
- double blind
- placebo controlled
- newly diagnosed
- ejection fraction
- healthcare
- respiratory failure
- drug induced
- peritoneal dialysis
- prognostic factors
- south africa
- study protocol
- dendritic cells
- aortic dissection
- adverse drug
- randomized controlled trial
- acute care
- electronic health record
- monoclonal antibody
- structural basis
- chemotherapy induced