Meta-analysis of direct-to-surgery lateral pelvic lymph node dissection for rectal cancer.
Benjamin I CribbJoseph Cherng Huei KongJacob McCormickSatish WarrierAlexander HeriotPublished in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2021)
In the published literature, direct-to-surgery resection with LPLND was associated with worse local and total recurrence. These predominantly nonrandomized data suggest that a nonselective approach to LPLND does not provide optimal management in radiotherapy-naïve patients with low rectal cancer. Further prospective randomized studies with a focus on patient selection are required.
Keyphrases
- rectal cancer
- locally advanced
- minimally invasive
- systematic review
- coronary artery bypass
- neoadjuvant chemotherapy
- case control
- meta analyses
- surgical site infection
- open label
- early stage
- radiation therapy
- squamous cell carcinoma
- randomized controlled trial
- prostate cancer
- lymph node
- placebo controlled
- clinical trial
- phase ii
- big data