Polysomnography versus limited respiratory monitoring and nurse-led titration to optimise non-invasive ventilation set-up: a pilot randomised clinical trial.
Maxime PatoutGill ArbaneAntoine CuvelierJean Francois MuirNicholas HartPatrick Brian MurphyPublished in: Thorax (2018)
Polysomnography (PSG) is recommended for non-invasive ventilation (NIV) set-up in patients with chronic respiratory failure. In this pilot randomised clinical trial, we compared the physiological effectiveness of NIV set-up guided by PSG to limited respiratory monitoring (LRM) and nurse-led titration in patients with COPD-obstructive sleep apnoea (OSA) overlap. The principal outcome of interest was change in daytime arterial partial pressure of carbon dioxide (PaCO2) at 3 months. Fourteen patients with daytime PaCO2 >6 kPa and body mass index >30 kg/m2 were recruited. At 3 months, PaCO2 was reduced by -0.88 kPa (95% CI -1.52 to -0.24 kPa) in the LRM group and by -0.36 kPa (95% CI -0.96 to 0.24 kPa) in the PSG group. These pilot data provide support to undertake a clinical trial investigating the clinical effectiveness of attended limited respiratory monitoring and PSG to establish NIV in patients with COPD-OSA overlap. TRIAL NUMBER: Results, NCT02444806.
Keyphrases
- clinical trial
- obstructive sleep apnea
- respiratory failure
- study protocol
- positive airway pressure
- randomized controlled trial
- phase ii
- open label
- carbon dioxide
- double blind
- mechanical ventilation
- body mass index
- phase iii
- sleep apnea
- extracorporeal membrane oxygenation
- chronic obstructive pulmonary disease
- sleep quality
- systematic review
- primary care
- placebo controlled
- physical activity
- respiratory tract
- intensive care unit
- electronic health record
- weight gain
- depressive symptoms
- artificial intelligence