Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia.
Shinobu TsuzukiTakahiko YasudaShinya KojimaMasahito KawazuKoshi AkahaneTakeshi InukaiMasue ImaizumiTakanobu MorishitaKoichi MiyamuraToshihide UenoSivasundaram KarnanAkinobu OtaToshinori HyodoHiroyuki KonishiMasashi SanadaHirokazu NagaiKeizo HoribeAkihiro TomitaKyogo SuzukiHideki MuramatsuYoshiyuki TakahashiYasushi MiyazakiItaru MatsumuraHitoshi KiyoiYoshitaka HosokawaHiroyuki ManoFumihiko HayakawaPublished in: Blood cancer discovery (2020)
Cancer type-specific gene expression is governed by transcription factors involved in a highly interconnected autoregulatory loop called CRC. Here, we characterized fusion protein-driven CRC and identified its pharmacologic vulnerabilities, opening therapeutic avenues to indirectly target fusion-driven leukemia by disrupting its CRC.See related commentary by Sadras and Müschen, p. 18. This article is highlighted in the In This Issue feature, p. 5.