Host-derived CEACAM-laden vesicles engage enterotoxigenic E. coli for elimination and toxin neutralization.
Alaullah SheikhDebayan GanguliTim J VickersBernhard B SingerJennifer D Foulke-AbelMarjahan AkhtarNazia KhatoonBipul SetuSupratim BasuClayton HarroNicole MaierWandy L BeattySubhra ChakrabortyTaufiqur Rahman BhuiyanFirdausi QadriMark DonowitzJames M FleckensteinPublished in: bioRxiv : the preprint server for biology (2024)
characterized by the production of heat-labile (LT) and heat-stable (ST) toxins, are a very common cause of diarrhea in low-income regions responsible for hundreds of millions of infections each year, and the major cause of diarrhea in travelers to endemic areas. Although these infections may be severe and cholera-like, they are typically self-limited. These studies demonstrate that extracellular vesicles produced by host intestinal cells can capture the bacteria and its secreted toxins at a distance from the cell surface, potentially acting as molecular decoys to neutralize the enterotoxins and extinguish the infection.