The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas.
Guillaume BeinsePierre-Alexandre JustBastien RanceBrigitte IzacFranck LetourneurNathaniel Edward Bennett SaiduSandrine ChouzenouxCarole NiccoFrançois GoldwasserEric PasmantFrederic BatteuxBruno BorgheseJérôme AlexandreKaren LeroyPublished in: PloS one (2019)
In contrast with previous reports based on immunohistochemistry, our study indicates that NRF2 activation is a rare event in EC, associated with NFE2L2 or KEAP1 mutations. The subset of aggressive EC with low NQO1 mRNA level might represent a specific subgroup, which could be sensitive to combination therapies targeting oxidative stress.
Keyphrases
- oxidative stress
- dna damage
- gene expression
- ischemia reperfusion injury
- magnetic resonance
- diabetic rats
- induced apoptosis
- binding protein
- transcription factor
- high grade
- cancer therapy
- clinical trial
- heat shock
- magnetic resonance imaging
- computed tomography
- adverse drug
- randomized controlled trial
- protein protein
- small molecule
- signaling pathway
- open label
- study protocol