Differential Temporal Dynamics of Axial and Appendicular Ataxia in SCA3.

Roderick P P W M MaasSteven TeerenstraManuela LimaPaula PiresLuis Pereira de AlmeidaJudith van GaalenDagmar TimmannJon InfanteChiadi OnyikeKhalaf BusharaHeike Jacobi Kathrin ReetzMagda M SantanaJoana Afonso Ribeiro Jeannette HübenerJeroen J de VriesMatthis SynofzikLudger SchölsHector Garcia-MorenoPaola GiuntiJennifer FaberThomas KlockgetherBart P C van de Warrenburg

Published in: Movement disorders : official journal of the Movement Disorder Society (2022)

Our findings provide evidence for a difference in temporal dynamics between axial and appendicular ataxia in SCA3 patients, which will help inform the design of clinical trials and development of new (etiology-specific) outcome measures. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

clinical trial
end stage renal disease
ejection fraction
newly diagnosed
early onset
randomized controlled trial
systematic review
meta analyses