EGFR and EGFRvIII coopt host defense pathways, promoting progression in glioblastoma.

Zhenyi AnQi-Wen FanLinyu WangHiroyuki YodaMegumi J BarataDavid Jimenez-MoralesJoanna J PhillipsDanielle L SwaneyErica StevensonEthan LeeNevan KroganWilliam A Weiss

Published in: Neuro-oncology (2024)

Together, our findings show that EGFR and EGFRvIII cooperate to drive tumor progression through ROCK2 and downstream WNT-β-catenin/TLR2 signaling pathways.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
cell proliferation
signaling pathway
epithelial mesenchymal transition
toll like receptor
stem cells
inflammatory response
poor prognosis
immune response
pi k akt
nuclear factor
induced apoptosis
long non coding rna
innate immune