Proteome-wide Analyses Identified Cortical Proteins Associated With Resilience for Varied Cognitive Abilities.

Andrea R ZammitHans-Ulrich KleinLei YuAllan I LeveyNicholas T SeyfriedAliza P WingoThomas S WingoJulie A SchneiderDavid A Bennett Aron S Buchman

Published in: Neurology (2023)

This study identified cortical proteins associated with various cognitive abilities. Differential associations across abilities may reflect distinct underlying biological pathways. These data provide potential high-value targets for further mechanistic and drug discovery studies to develop targeted treatments to prevent loss of cognition.

Keyphrases

drug discovery
electronic health record
mild cognitive impairment
cancer therapy
white matter
multiple sclerosis
drug delivery
depressive symptoms