LncRNA PVT1 Mediates Antiapoptosis and 5-Fluorouracil Resistance via Increasing Bcl2 Expression in Gastric Cancer.

Peizhun DuCheng'en HuYunyun QinJing ZhaoRajan PatelYan FuMengqi ZhuWenhong Zhang Guangjian Huang

Published in: Journal of oncology (2019)

Our results showed that PVT1 can inhibit the apoptosis and enhance the 5-Fu resistance of gastric cancer through the activation of Bcl2. PVT1 has the potential to serve as an indicator to predict 5-Fu treatment resistance.

Keyphrases

poor prognosis
oxidative stress
cell death
endoplasmic reticulum stress
long non coding rna
risk assessment
combination therapy