NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation.

Mina NouraSakura TomitaTakahiko YasudaShinobu TsuzukiHitoshi KiyoiFumihiko Hayakawa

Published in: Cancer medicine (2024)

We demonstrated the pivotal role of NB in cell transformation and survival and identified PIM1as a key downstream target of NB. These findings propose a promising therapeutic strategy for patients with NB fusion-positive leukemia.

Keyphrases

single cell
acute myeloid leukemia
bone marrow
cell therapy
cell proliferation
poor prognosis
signaling pathway
transcription factor
stem cells
long non coding rna