Association of the Drug Burden Index (DBI) exposure with outcomes: A systematic review.

Bonnie M LiuLisa Kouladjian O'DonnellMitchell R RedstonKenji FujitaJanani ThillainadesanDanijela GnjidicSarah N Hilmer

Published in: Journal of the American Geriatrics Society (2023)

A higher DBI may be associated with an increased risk of falls and decreased function and cognition. Higher DBI was inconsistently associated with increased mortality, length of stay, frailty, hospitalization or reduced quality of life. Human observational findings with respect to functional outcomes are supported by preclinical interventional studies. The DBI may be used as a tool to identify older adults at higher risk of harm.

Keyphrases

endothelial cells
physical activity
risk factors
community dwelling
mild cognitive impairment
type diabetes
emergency department
cross sectional
white matter
cell therapy
multiple sclerosis
bone marrow
adverse drug
skeletal muscle