Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling.

Ryland D MortlockSenta K GeorgiaStacey D Finley

Published in: Cellular and molecular bioengineering (2020)

JAK-STAT signaling must be tightly controlled to obtain the biphasic response in STAT5 activation seen experimentally. Receptor up-regulation, combined with SOCS inhibition, receptor internalization, or both is required to match experimental data. Modulating reactions upstream in the signaling can enhance STAT5 activation to increase beta cell survival.

Keyphrases

cell proliferation
electronic health record
binding protein
deep learning
artificial intelligence