Widespread domain-like perturbations of DNA methylation in whole blood of Down syndrome neonates.

Peter HennemanArjan BoumanAdri MulLia KnegtAnne-Marie van der Kevie-KersemaekersNitash Zwaveling-SoonawalaHanne E J Meijers-HeijboerA S Paul van TrotsenburgMarcel M Mannens

Published in: PloS one (2018)

In this study, we found methylation profile differences between DS newborns and controls reflecting a systematically affected epigenetic profile. The observed chromosome 21 dosage effect suggests the involvement of affected essential regulatory factors/regions or altered expression of chromatin modeling enzymes located on chromosome 21. Additional research is necessary to substantiate these hypotheses.

Keyphrases

dna methylation
genome wide
gene expression
copy number
transcription factor
low birth weight
poor prognosis
pregnant women
dna damage
gestational age
binding protein
preterm birth
oxidative stress