AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation.
Yoichi SekitaYuki SugiuraAkari MatsumotoYuki KawasakiKazuya AkasakaRyo KonnoMomoka ShimizuToshiaki ItoEiji SugiyamaTerushi YamazakiEriko KanaiToshinobu NakamuraMakoto SuematsuFumitoshi IshinoYoshio KoderaTakashi KohdaTohru KimuraPublished in: Stem cell research & therapy (2021)
These results suggest the possibility that the activation of AKT during somatic cell reprogramming promotes epigenetic reprogramming through the hyperactivation of TET at the transcriptional and catalytic levels.