AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation.

Yoichi SekitaYuki SugiuraAkari MatsumotoYuki KawasakiKazuya AkasakaRyo KonnoMomoka ShimizuToshiaki ItoEiji SugiyamaTerushi YamazakiEriko KanaiToshinobu NakamuraMakoto SuematsuFumitoshi IshinoYoshio KoderaTakashi KohdaTohru Kimura

Published in: Stem cell research & therapy (2021)

These results suggest the possibility that the activation of AKT during somatic cell reprogramming promotes epigenetic reprogramming through the hyperactivation of TET at the transcriptional and catalytic levels.

Keyphrases

signaling pathway
cell proliferation
gene expression
dna methylation
single cell
cell therapy
transcription factor
poor prognosis
copy number
stem cells
genome wide
bone marrow
crystal structure
heat shock