Comparative Effectiveness of Regimens for Drug-Susceptible Tuberculous Meningitis in Children and Adolescents: A Systematic Review and Aggregate-Level Data Meta-Analysis.

Giorgia Sulis Gamuchirai Tavaziva Genevieve Gore Andrea Benedetti Regan S Solomons Ronald van Toorn Stephanie Thee Jeremy N Day Sabine Verkuijl Annemieke Brands Kerri Viney Tiziana Masini Faiz Ahmad KhanSilvia S Chiang

Published in: Open forum infectious diseases (2022)

Our findings are limited by the small number of studies and substantial potential for confounding. Nonetheless, the 6HRZEto regimen was associated with high treatment success and is now recommended by WHO as an alternative to the 12-month regimen.

Keyphrases

systematic review
case control
meta analyses
electronic health record
combination therapy
randomized controlled trial
machine learning