Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice.

Richard F LoeserKathryn L KelleyAlexandra ArmstrongJohn A CollinsBrian O DiekmanCathy S Carlson

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

JNK1 and JNK2 are not required for the development of OA in the mouse DMM model. Deletion of JNK1 or JNK2 is associated with more severe age-related OA and increased cell senescence, suggesting that JNK may act as a negative regulator of senescence in the joint.

Keyphrases

signaling pathway
cell death
induced apoptosis
dna damage
endothelial cells
knee osteoarthritis
stress induced
endoplasmic reticulum stress
rheumatoid arthritis
gene expression
oxidative stress
type diabetes
early onset
adipose tissue
insulin resistance
metabolic syndrome