DNA methylation analysis reveals epimutation hotspots in patients with dilated cardiomyopathy-associated laminopathies.

Julien L P MorivalHalida P WidyastutiCecilia H H NguyenMichael V ZaragozaTimothy L Downing

Published in: Clinical epigenetics (2021)

Our results identified both shared and mutation-specific laminopathy epimutation landscapes that were consistent with lamin A/C mutation-mediated epigenetic aberrancies that arose in somatic and early developmental cell stages.

Keyphrases

dna methylation
gene expression
genome wide
copy number
single cell
cell therapy
stem cells
mesenchymal stem cells