Identification of redundancy between human FcεRIβ and MS4A6A proteins points toward additional complex mechanisms for FcεRI trafficking and signaling.
Katie BittingBarry A HedgespethLauren C Ehrhardt-HumbertGreer K ArthurAlicia G SchubertPeter BraddingStephen L TilleyGlenn CrusePublished in: Allergy (2022)
Our data suggest the presence of either FcεRIβ or MS4A6A is sufficient for degranulation, indicating that MS4A6A could be an elusive FcεRIβ-like protein in human MCs that performs compensatory functions in allergic disease.