Mediating Role of Bone Marrow Lesions, Synovitis, Pain Sensitization, and Depressive Symptoms on Knee Pain Improvement Following Substantial Weight Loss.
S Reza JafarzadehTuhina NeogiJoshua J StefanikJing-Sheng LiAli GuermaziCaroline M ApovianDavid T FelsonPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Weight loss-induced knee pain improvement is partially mediated by changes in pain sensitization and depressive symptoms but is independent of MRI changes in BMLs and synovitis.
Keyphrases
- chronic pain
- depressive symptoms
- weight loss
- pain management
- neuropathic pain
- bone marrow
- bariatric surgery
- total knee arthroplasty
- magnetic resonance imaging
- social support
- roux en y gastric bypass
- gastric bypass
- metabolic syndrome
- knee osteoarthritis
- physical activity
- spinal cord injury
- spinal cord
- body mass index
- magnetic resonance
- insulin resistance
- high glucose
- oxidative stress
- contrast enhanced
- diabetic rats