Effect of Intravenous Zoledronic Acid on Total Knee Replacement in Patients With Symptomatic Knee Osteoarthritis and Without Severe Joint Space Narrowing: A Prespecified Secondary Analysis of a Two-Year, Multicenter, Double-Blind, Placebo-Controlled Clinical Trial.
Guoqi CaiLaura Louise LaslettMichael ThompsonFlavia M CicuttiniCatherine L HillAnita E WlukaLyn MarchYuanyuan WangPetr OtahalJames D StoneyBenny AntonyKathy ButtigiegTania WinzenbergGraeme JonesDawn AitkenPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
These results suggest that ZA is not protective against TKR in patients with symptomatic knee osteoarthritis and without severe JSN.