Mg2+ Transporters in Digestive Cancers.
Julie AuwercxPierre RybarczykPhilippe KischelIsabelle Dhennin-DuthilleDenis ChatelainHenri SevestreIsabelle van SeuningenHalima Ouadid-AhidouchNicolas JonckheereMathieu GautierPublished in: Nutrients (2021)
Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this review, we describe the expression of Mg2+ transporters in digestive cancers, the most common and deadliest malignancies worldwide. Moreover, Mg2+ transporters' expression, correlation and impact on patient overall and disease-free survival is analyzed using Genotype Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Finally, we discuss the role of these Mg2+ transporters in the regulation of cancer cell fates and oncogenic signaling pathways.
Keyphrases
- poor prognosis
- binding protein
- single cell
- ionic liquid
- signaling pathway
- dna methylation
- cell proliferation
- young adults
- cell therapy
- genome wide
- epithelial mesenchymal transition
- climate change
- long non coding rna
- papillary thyroid
- rna seq
- brain injury
- mesenchymal stem cells
- big data
- lymph node metastasis
- endoplasmic reticulum stress
- subarachnoid hemorrhage
- squamous cell
- protein protein