Closed-Loop Acoustic Stimulation During Sedation with Dexmedetomidine (CLASS-D): Protocol for a Within-Subject, Crossover, Controlled, Interventional Trial with Healthy Volunteers.
Christian S GuayAlyssa K LabonteMichael C MontanaEric C LandsnessBrendan P LuceyMohammadMehdi KafashanSimon HaroutounianMichael S AvidanEmery N BrownBen Julian Agustin PalancaPublished in: Nature and science of sleep (2021)
This investigation will elucidate 1) the potential of exogenous sensory stimulation to potentiate SWA during sedation; 2) the physiologic significance of this intervention; and 3) the connection between EEG slow-waves observed during sleep and sedation.
Keyphrases
- mechanical ventilation
- randomized controlled trial
- study protocol
- clinical trial
- phase iii
- functional connectivity
- working memory
- cardiac surgery
- open label
- phase ii
- acute respiratory distress syndrome
- resting state
- double blind
- human health
- depressive symptoms
- risk assessment
- placebo controlled
- climate change
- high density
- extracorporeal membrane oxygenation