A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics.

Xin PengCong ZhangZhi-Min ZhouKun WangJia-Wei GaoZhan-Yang QianJun-Ping BaoHang-Yu JiV L F CabralXiao-Tao Wu

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2022)

To sum up, A20 attenuates pyroptosis and apoptosis of NP cells via promoting mitophagy and stabilizing mitochondrial dynamics. Besides, A20 reduces LPS-induced NP cell apoptosis by inhibiting NLRP3 inflammasome-mediated pyroptosis. It provides theoretical support for the reduction of functional NP cell loss in the intervertebral disc through the gene-targeted intervention of A20.

Keyphrases

nlrp inflammasome
cell cycle arrest
induced apoptosis
oxidative stress
cell death
lps induced
endoplasmic reticulum stress
pi k akt
inflammatory response
signaling pathway
randomized controlled trial
single cell
stem cells
cancer therapy
dna methylation
bone marrow
drug delivery