Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology.

Tirsa L E van WesteringYulia LomonosovaAnna M L Coenen-StassCorinne A BettsAmarjit BhomraMargriet HulskerLucy E ClarkGraham McCloreyAnnemieke Aartsma-RusMaaike van PuttenMatthew J A WoodThomas C Roberts

Published in: Journal of cachexia, sarcopenia and muscle (2019)

Uniform dystrophin expression is required to prevent ex-miRNA release, stabilize myofiber turnover, and attenuate pathology in dystrophic muscle.

Keyphrases

poor prognosis
duchenne muscular dystrophy
muscular dystrophy
binding protein
bone mineral density