Male infertility is associated with differential DNA methylation signatures of the imprinted gene GNAS and the non-imprinted gene CEP41.
Suheyla Esra OzkocerIsmail GulerAsiye Ugras DikmenNuray BozkurtNuray VarolEce KonacPublished in: Journal of assisted reproduction and genetics (2024)
The disappearance of the relationship between IGF2 expression and IGF2AS and H19 methylations in the infertile group provides new information regarding the disruption of epigenetic programming during spermatogenesis. A better understanding of sperm GNASAS and CEP41 hypermethylation could advance innovative diagnostic markers for male infertility.
Keyphrases
- dna methylation
- genome wide
- copy number
- polycystic ovary syndrome
- binding protein
- gene expression
- poor prognosis
- pi k akt
- genome wide identification
- growth hormone
- type diabetes
- healthcare
- insulin resistance
- health information
- metabolic syndrome
- cell proliferation
- long non coding rna
- high resolution
- transcription factor