Status of nutrients important in brain function in phenylketonuria: a systematic review and meta-analysis.
Gina A MontoyaRani H SinghAysun Cetinyurek-YavuzMirjam KuhnAnita MacDonaldPublished in: Orphanet journal of rare diseases (2018)
The current data show that PKU patients have lower availability of DHA, EPA and cholesterol. Compliance with the phe-restricted diet including the micronutrient fortified protein substitute (PS) is essential to ensure adequate micronutrient status. Given the complexity of the diet, patients' micronutrient and fatty acid status should be continuously monitored, with a particular focus on patients who are non-compliant or poorly compliant with their PS. Given their key role in brain function, assessment of the status of nutrients where limited data was found (e.g. choline, iodine) should be undertaken. Standardised reporting of studies in PKU would strengthen the output of meta-analysis and so better inform best practice for this rare condition.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- systematic review
- peritoneal dialysis
- fatty acid
- physical activity
- emergency department
- healthcare
- computed tomography
- multiple sclerosis
- weight loss
- white matter
- heavy metals
- magnetic resonance
- quality improvement
- subarachnoid hemorrhage
- patient reported
- blood brain barrier
- binding protein
- deep learning
- cerebral ischemia