Patterns of protein expression in human head and neck cancer cell lines differ after proton vs photon radiotherapy.

Li WangLiuqing YangShichao HanJinming ZhuYuting LiZeming WangYou-Hong FanEric LinRuiping ZhangNarayan SahooYupeng LiXiaodong ZhangXiaochun WangTengfei LiXiaorong R ZhuHongtu ZhuJohn V HeymachJeffrey N MyersSteven J Frank

Published in: Head & neck (2019)

Under these experimental conditions, PRT and XRT induced different protein expression and activation profiles. Further preclinical verification is needed, as are studies of tumor pathway mutations as biomarkers for choice of treatment or as radiosensitization targets to improve the response of HNSCC to PRT or XRT.

Keyphrases

endothelial cells
high glucose
early stage
radiation therapy
diabetic rats
squamous cell carcinoma
pluripotent stem cells
drug induced
radiation induced
cell therapy
case control
living cells
decision making
fluorescent probe