Patterns of protein expression in human head and neck cancer cell lines differ after proton vs photon radiotherapy.
Li WangLiuqing YangShichao HanJinming ZhuYuting LiZeming WangYou-Hong FanEric LinRuiping ZhangNarayan SahooYupeng LiXiaodong ZhangXiaochun WangTengfei LiXiaorong R ZhuHongtu ZhuJohn V HeymachJeffrey N MyersSteven J FrankPublished in: Head & neck (2019)
Under these experimental conditions, PRT and XRT induced different protein expression and activation profiles. Further preclinical verification is needed, as are studies of tumor pathway mutations as biomarkers for choice of treatment or as radiosensitization targets to improve the response of HNSCC to PRT or XRT.