Examining evidence of time-dependent treatment effects: an illustration using regression methods.
Kim M JachnoStephane HeritierRobyn L WoodsSuzanne MahadyAndrew ChanAndrew TonkinAnne MurrayJohn J McNeilRory WolfePublished in: Trials (2022)
The consideration of treatment effects using both absolute and relative estimands enhanced clinical insights into potential dynamic treatment effects. We recommend these analytical approaches as an adjunct to primary analyses to fully explore findings from clinical trials.