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Multiplex profiling of inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis.

Patrick WaindokElisabeth Janecek-ErfurthDimitri LindenwaldEsther WilkKlaus SchughartRobert GeffersLaurence BalasThierry DurandKatharina Maria RundNils Helge SchebbChristina Strube
Published in: PLoS neglected tropical diseases (2019)
The obtained results demonstrate the influence of Toxocara spp. on oxylipins as part of the immune response of the paratenic hosts. Furthermore, this study shows differences in the alteration of the oxylipin composition between T. canis- and T. cati-brain infection. Results contribute to a further understanding of the largely unknown pathogenesis and mechanisms of host-parasite interactions during NT.
Keyphrases
  • immune response
  • oxidative stress
  • high glucose
  • diabetic rats
  • drug induced
  • white matter
  • single cell
  • fatty acid
  • trypanosoma cruzi
  • life cycle