Apatinib Inhibits the Invasion and Metastasis of Liver Cancer Cells by Downregulating MMP-Related Proteins via Regulation of the NF-κB Signaling Pathway.

Xiaoxiao HeZaozao HuangPing LiuQiuting LiMengmeng WangMengjun QiuZhi-Fan Xiong Sheng-Li Yang

Published in: BioMed research international (2020)

Apatinib inhibits the invasion and metastasis of human liver cancer cells by downregulating the expression of MMP-related genes. This may be achieved by inhibiting the activation of the NF-κB signaling pathway.

Keyphrases

signaling pathway
cell migration
pi k akt
induced apoptosis
epithelial mesenchymal transition
poor prognosis
binding protein
nuclear factor