HIV-1 Nef acts in synergy with APOL1-G1 to induce nephrocyte cell death in a new Drosophila model of HIV-related kidney diseases.
Jun-Yi ZhuYulong FuJoyce van de LeemputYing YuJinliang LiPatricio E RayZhe HanPublished in: bioRxiv : the preprint server for biology (2024)
nephrocytes and human podocytes, this finding suggests ER stress as a new therapeutic target for HIV-1 and APOL1-associated nephropathies.