Nanoparticle delivery of miR-21-3p sensitizes melanoma to anti-PD-1 immunotherapy by promoting ferroptosis.

Weinan GuoZhenjie WuJianru ChenSen GuoWeiming YouSijia WangJinyuan MaHuina WangXiangxu WangHao WangJingjing MaYuqi YangYangzi TianQiong ShiTianwen GaoXiuli YiChunying Li

Published in: Journal for immunotherapy of cancer (2022)

MiR-21-3 p upregulation contributes to IFN-γ-driven ferroptosis and synergizes with anti-PD-1 antibody. Nanoparticle delivery of miR-21-3 p is a promising therapeutic approach to increase immunotherapy efficacy without obvious systemic side effects.

Keyphrases

cell death
iron oxide
immune response
cell proliferation
poor prognosis
dendritic cells
signaling pathway
induced apoptosis
oxidative stress
skin cancer