Login / Signup

Brazilian green propolis promotes TNFR2 expression on regulatory T cells.

Norihisa MikamiHiroko TaniRyoji KawakamiAtsushi SugimotoShimon SakaguchiTomoki Ikuta
Published in: Food science & nutrition (2021)
FoxP3+ regulatory T cells (Tregs) are needed to suppress inflammatory diseases and maintain immune homeostasis. The suppressive function of Tregs can be used to control autoimmune or inflammatory diseases; therefore, it is well studied how Tregs can be artificially up- or downregulated in vitro and in vivo, by using antibodies, chemical compounds, foods, and natural resources. Propolis is a famous functional food that has an anti-inflammatory effect. However, the influences of propolis on Treg function have not been fully evaluated so far. Here, we demonstrated that Brazilian green propolis increases TNFR2 expression in Tregs via the IRF4/cMyc axis, and artepillin C was a major effective component of propolis on Tregs. These results indicate that propolis and artepillin C have the potential as Treg activators via TNFR2 expression and may be useful for the prevention and/or therapy of autoimmune or inflammatory diseases.
Keyphrases
  • regulatory t cells
  • dendritic cells
  • poor prognosis
  • oxidative stress
  • anti inflammatory
  • multiple sclerosis
  • binding protein
  • stem cells
  • immune response
  • long non coding rna
  • bone marrow
  • drug induced
  • solid state