Comparative Effectiveness and Safety of Direct Oral Anticoagulants Compared with Warfarin in Patients with Low Bodyweight who have Atrial Fibrillation: A Systematic Review and Meta-analysis.
Mohamed Nabil ElshafeiAhmed El-BardissyMuhammad SalemMohamed S AbdelmoneimAhmed KhalilSherine ElhadadMohammed DanjumaPublished in: American journal of cardiovascular drugs : drugs, devices, and other interventions (2024)
) was associated with a significant reduction in risks of stroke and major bleeding compared with patient cohorts stabilized on warfarin-based therapy. There was uncertainty regarding the composite outcome and mortality point estimate between these two anticoagulation strategies. This finding helps to resolve the uncertainty associated with the use of DOACs in this cohort. Additionally, it suggests the need for confirmatory non-inferiority randomized controlled trials evaluating DOACs versus warfarin in this cohort of patients.
Keyphrases
- direct oral anticoagulants
- atrial fibrillation
- venous thromboembolism
- oral anticoagulants
- catheter ablation
- left atrial
- left atrial appendage
- end stage renal disease
- heart failure
- ejection fraction
- randomized controlled trial
- chronic kidney disease
- percutaneous coronary intervention
- newly diagnosed
- peritoneal dialysis
- stem cells
- cardiovascular events
- cardiovascular disease
- systematic review
- type diabetes
- climate change
- human health
- left ventricular
- meta analyses
- replacement therapy
- patient reported