Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis.
Moeed AkbarDerek S GilchristSusan M KitsonBriana NelisLindsay A N CroweEmma Garcia-MelchorJames H ReillyShauna C KerrGeorge A C MurrellIain B McInnesNeal L MillarPublished in: RMD open (2017)
HMGB1 is present in human tendinopathy and can regulate inflammatory cytokines and matrix changes. We propose HMGB1 as a mediator driving the inflammatory/matrix crosstalk and manipulation of the HMGB1/TLR4 axis may offer novel therapeutic approaches targeting inflammatory mechanisms in the management of human tendon disorders.