Treatment of necrotizing enterocolitis by conditioned medium derived from human amniotic fluid stem cells.

Joshua S O'Connell Bo LiAndrea ZitoAbdalla AhmedMarissa CadeteNiloofar GanjiEthan LauMashriq AlganabiNassim FarhatCarol LeeSimon EatonRobert MitchellSteve RayPaolo De CoppiKetan PatelAgostino Pierro

Published in: PloS one (2021)

CM derived from human AFSC administered in experimental NEC exhibited various benefits including reduced intestinal injury and inflammation, increased enterocyte proliferation, and restored intestinal stem cell activity. This study provides the scientific basis for the use of CM derived from AFSC in neonates with NEC.

Keyphrases

stem cells
endothelial cells
induced pluripotent stem cells
pluripotent stem cells
low birth weight
oxidative stress
cell therapy
combination therapy
preterm birth
smoking cessation