Clinical validation of engineered CRISPR/Cas12a for rapid SARS-CoV-2 detection.

Long T NguyenSantosh R RananawareBrianna L M PizzanoBrandon T StonePiyush K Jain

Published in: Communications medicine (2022)

CRISPR-based diagnostic platforms offer many advantages as compared to conventional qPCR-based detection methods. Our work here provides clinical validation of ENHANCE and its improved form ENHANCEv2 for the detection of COVID-19.

Keyphrases

sars cov
loop mediated isothermal amplification
crispr cas
genome editing
real time pcr
label free
coronavirus disease
genome wide
sensitive detection