Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment.

Meng QiaoFei ZhouXinyu LiuTao JiangHaowei WangXuefei LiChao ZhaoLei ChengXiaoxia ChenShengxiang RenZaiqi WangCaicun Zhou

Published in: Experimental hematology & oncology (2024)

Our study identified FAK as a promising intervention target for KL tumors and provided basis for the combination of FAK inhibitor with PD-1 blockade in the management of KL lung cancers.

Keyphrases

immune response
cell migration
randomized controlled trial
wild type
dendritic cells
tyrosine kinase
biofilm formation
pseudomonas aeruginosa
escherichia coli
young adults
drug delivery
protein kinase