Hepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies.

José Francisco Català-Senent Marta R Hidalgo Marina C Berenguer Gopanandan Parthasarathy Harmeet Malhi Pablo Malmierca-Merlo María de la Iglesia-Vayá Francisco García-García

Published in: Biology of sex differences (2021)

Our meta-analysis of transcriptomic data provides a powerful approach to identify sex-based differences in NAFLD. We detected differences in relevant biological functions and molecular terms between premenopausal women and men. Differences in immune responsiveness between men and premenopausal women with NAFLD suggest that women possess a more immune tolerant milieu, while men display an impaired liver regenerative response.

Keyphrases

systematic review
case control
polycystic ovary syndrome
stem cells
postmenopausal women
breast cancer risk
middle aged
meta analyses
single cell
mesenchymal stem cells
rna seq
type diabetes
randomized controlled trial
cell therapy
adipose tissue
big data
electronic health record
deep learning