About 40 years ago, the large and small tumor antigens (LT-Ag and sT-Ag) of the polyomavirus (PyVs) simian vacuolating virus 40 have been identified and characterized. To date, it is well known that all the discovered human PyVs (HPyVs) encode these 2 multifunctional and tumorigenic proteins, expressed at viral replication early stage. The 2 T-Ags are able to transform cells both in vitro and in vivo and seem to play a distinct role in the pathogenesis of some tumors in humans. In addition, they are involved in viral DNA replication, transcription, and virion assembly. This short review focuses on the structural and functional features of the HPyVs' LT-Ag and sT-Ag, with special attention to their transforming properties.
Keyphrases
- quantum dots
- early stage
- endothelial cells
- highly efficient
- visible light
- induced apoptosis
- induced pluripotent stem cells
- dendritic cells
- pluripotent stem cells
- drug delivery
- working memory
- transcription factor
- cell cycle arrest
- cell death
- squamous cell carcinoma
- radiation therapy
- lymph node
- cancer therapy
- cell proliferation
- metal organic framework