Safety and Virologic Impact of Haploidentical NK Cells Plus Interleukin 2 or N-803 in HIV Infection.
Jeffrey S MillerJoshua RheinZachary B DavisSarah CooleyDavid McKennaJodi AndersonKevin Escandón-VargasGarritt WiekingJarrett ReichelAnn ThorkelsonSiri JorstadJeffrey T SafritPatrick Soon-ShiongGregory J BeilmanJeffrey G ChipmanTimothy W SchackerPublished in: The Journal of infectious diseases (2024)
There was a moderate decrease in HIV-producing cells in lymph nodes. Further studies are warranted to determine the impact of healthy NK cells on HIV reservoirs and if restoring NK-cell function could be part of an HIV cure strategy. Clinical Trials Registration. NCT03346499 and NCT03899480.
Keyphrases
- antiretroviral therapy
- nk cells
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv testing
- hiv aids
- clinical trial
- lymph node
- hepatitis c virus
- men who have sex with men
- induced apoptosis
- south africa
- bone marrow
- randomized controlled trial
- stem cell transplantation
- high intensity
- endoplasmic reticulum stress
- cord blood
- peripheral blood
- cell proliferation
- early stage
- phase ii
- phase iii