DKK3 expression is associated with immunosuppression and poor prognosis in glioblastoma, in contrast to lower-grade gliomas.

Myung-Hoon HanJeong Min BaekKyueng Whan MinJin Hwan CheongJe Il RyuYu Deok WonMi Jung KwonSeong-Ho Koh

Published in: BMC neurology (2023)

According to our findings, DKK3 expression had a weak effect on LGG but a significant effect on immunosuppression and poor prognosis in GBM. Therefore, DKK3 expression seems to play different roles, through the Wnt/β-catenin pathway, between LGG and GBM.

Keyphrases

poor prognosis
long non coding rna
magnetic resonance
stem cells
cell proliferation
computed tomography
contrast enhanced