Phospholipid isotope tracing reveals β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma.

Chad VanSant-WebbHayden K LowJunko KuramotoClaire E StanleyHantao QiangAudrey SuAlexis N RossChad G CooperJames E CoxScott A SummersKimberley J EvasonGregory S Ducker

Published in: bioRxiv : the preprint server for biology (2023)

leads to conserved changes in lipid metabolism in hepatocellular carcinoma. These include the stimulation of fatty acid oxidation and a suppression of phosphorylcholine synthesis.

Keyphrases

fatty acid
epithelial mesenchymal transition
cell proliferation
transcription factor
hydrogen peroxide
nitric oxide
high resolution
mass spectrometry