Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?
Ramy YouneOlivier GovaereSalvatore PettaLuca MieleDina TiniakosAlastair BurtEzio DavidFabio Maria VecchioMarco MaggioniDaniela CabibiDuncan McLeodMaria Jesus ParejaAnna Ludovica FracanzaniRocio AllerChiara RossoJavier AmpueroRocío Gallego-DuránAngelo ArmandiGian Paolo CavigliaMarco Y W ZakiAntonio LiguoriPaolo FrancioneGrazia PennisiAntonio GriecoGiovanni BiroloPiero FariselliMohammed EslamLuca Vittorio ValentiJacob GeorgeManuel Romero-GómezQuentin Mark AnsteeElisabetta BugianesiPublished in: Gut (2021)
NAFLD may affect and progress in both obese and lean individuals. Lean subjects are predominantly males, have a younger age at diagnosis and are more prevalent in some geographic areas. During the follow-up, lean subjects can develop hepatic and extrahepatic disease, including metabolic comorbidities, in the absence of weight gain. These patients represent one end of a wide spectrum of phenotypic expression of NAFLD.
Keyphrases
- weight gain
- bone mineral density
- body mass index
- end stage renal disease
- weight loss
- newly diagnosed
- birth weight
- ejection fraction
- poor prognosis
- metabolic syndrome
- chronic kidney disease
- adipose tissue
- postmenopausal women
- bariatric surgery
- peritoneal dialysis
- body composition
- binding protein
- obese patients
- preterm birth