A Physiological Approach to Renal Clearance - from Premature Neonates to Adults.
Nick H G HolfordConor J O'HanlonKarel AllegaertBrian AndersonAmilcar FalcãoNicolas SimonYoke-Lin LoAlison H ThomsonCatherine M T SherwinÉvelyne M Jacqz-AigrainCarolina Llanos-PaezStefanie HennigLinas MockusCarl M J KirkpatrickPublished in: British journal of clinical pharmacology (2023)
GFR provides a physiological basis for renal drug elimination. It has been used to distinguish two elimination components. This physiological approach has been applied to describe clearance and volume of distribution from premature neonates to elderly adults with a wide dispersion of size, body composition and renal function. Dose individualization has been implemented using target concentration intervention.