The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the "DOSE-EX" multi-arm parallel-group randomised clinical trial.
Mark P P LyngbækGrit E LegaardSebastian L BennetsenCamilla S FeineisVillads RasmussenNana MoegelbergCecilie F BrinkløvAnette B NielsenKatja S KofoedCarsten A LauridsenCaroline EwertsenHenrik Enghusen PoulsenRobin ChristensenGerrit V HallKristian KarstoftThomas Phillip James SolomonHelga EllingsgaardThomas P AlmdalBente Klarlund PedersenMathias Ried-LarsenPublished in: Trials (2021)
The data from this study will add knowledge to which volume of exercise training in combination with a dietary intervention is needed to improve β-cell function in T2D. Secondarily, our results will elucidate mechanisms of physical activity mitigating the development of micro- and macrovascular complications correlated with T2D.