Genome-wide association study identifies TNFSF15 associated with childhood asthma.
Kyung Won KimDong Yun KimDankyu YoonKa-Kyung KimHaerin JangNathan SchoettlerEun Gyul KimMi Na KimJung Yeon HongJeom-Kyu LeeSangwoo KimCarole OberHeon Yung GeeMyung Hyun SohnPublished in: Allergy (2021)
Our GWAS of persistent childhood asthma with allergic sensitization identified a new susceptibility gene, TNFSF15, and replicated associations at the 17q12-21 childhood-onset asthma locus. This novel association may be mediated by reduced expression of serum TNFSF15 and loss of suppression of angiogenesis.