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CALHM2 V136G polymorphism reduces astrocytic ATP release and is associated with depressive symptoms and Alzheimer's disease risk.

Yang LiaoYingyi WangQing-Qing TaoChaoguang YangJinlei WangJinbo ChengJun MaZhi-Ying WuRui-Yuan PanZeng-Qiang Yuan
Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
CALHM2 dysfunction is a biologically relevant mechanism that may contribute to the observed clinical correlation between depression and AD.
Keyphrases
  • depressive symptoms
  • sleep quality
  • social support
  • cognitive decline
  • oxidative stress
  • physical activity
  • mild cognitive impairment